Methodologies

Peptide Literature

References

Product Use and Liability

Orexins, a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

Title

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior [see comments]

Author

Sakurai T; Amemiya A; Ishii M; Matsuzaki I; Chemelli RM; Tanaka H; Williams SC; Richardson JA; Kozlowski GP; Wilson S; Arch JR; Buckingham RE; Haynes AC; Carr SA; Annan RS; McNulty DE; Liu WS; Terrett JA; Elshourbagy NA; Bergsma DJ; Yanagisawa M

Source

Cell, 92(4):573-85 1998 Feb 20

Abstract

The hypothalamus plays a central role in the integrated control of feeding and energy homeostasis. We have identified two novel neuropeptides, both derived from the same precursor by proteolytic processing, that bind and activate two closely related (previously) orphan G protein-coupled receptors. These peptides, termed orexin-A and -B, have no significant structural similarities to known families of regulatory peptides. prepro-orexin mRNA and immunoreactive orexin-A are localized in neurons within and around the lateral and posterior hypothalamus in the adult rat brain. When administered centrally to rats, these peptides stimulate food consumption. prepro-orexin mRNA level is up-regulated upon fasting, suggesting a physiological role for the peptides as mediators in the central feedback mechanism that regulates feeding behavior.

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