Other Services

PEGylation

American Peptide Company, Inc. makes the case for slightly increasing the cost-of-goods of peptide APIs by chemical modification with PEG as a cost-effective trade-off for a potential increase in bioavailability over the injected naked peptide.

PEGylation is an FDA-approved delivery system for peptide and protein-based biopharmaceuticals. The process of specific PEGyaltion involves the chemical attachment of polyethylene glycol (PEG) to a therapeutic peptide or protein at a specific site on the molecule. Your API can have significantly improved therapeutic properties, including better patient compliance and side effect profile.

    Improved Pharamacokinetic Increased circulation time
  • enhances solubility
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  • decreases amount of API required
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  • improves stability
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  • decreases doing frequency
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  • sustains absorption
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  • optimizes biodistribution
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  • sustains biopharmaceutical action
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  • reduces renal clearance
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    Decreased toxicity    
  • improves safety profile
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  • reduces immunogenicity
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  • improves safety profile
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  • reduces proteolysis
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Key Advantages of our peptide engineering technologies with site-specific polyethylene glycol (PEG) modifications:

  • Increased intellectual property value
  • Site-specific modifications and linkers
  • Consistent lot to lot characterization and biological activity
  • Scaleable chemistry